Dna With Natural Catalysts - 902 Words

The approach described above is novel and original because we are integrating the high level of programmability of DNA with natural catalysts, which are very significant to progress in many different scientific fields. Such integration enables coupling of enzymes to circuits that are capable of decision making and self-regulation, leading to an unprecedented level of control of catalytic reactions. To achieve our objectives, we will develop methods to systematically design, model and test both dynamic and structural components. We will also create software and mathematical tools that can predict the dynamic behavior of individual catalytic modules and multi-modular circuits. When compared to existing techniques and protocols for multi-enzyme reactions, our system has multiple advantages: (1) Multi-enzyme reactions typically require laborious purification after each step and this can also result in loss of valuable sample. By sequestering enzymes within a crystal and then activating each enzyme one after another in proper order, we can avoid purification steps between each reaction. Leakage of enzymes from crystal lattice can be pre- vented using semi-permeable blockades that will block enzymes by will allow the substrate to pass in and out. (2) Enclosure inside crystal lattices will provide additional stability and protective cover to sensitive enzymes, thus keeping them active and stable for longer periods of time. (3) In case of multi-enzyme reactions, sequestering allShow MoreRelatedRna World Theory, A Possible Theory For Life Origin. I1534 Words   |  7 Pagesan RNA molecule is produced with the right sequence and folded into the right shape to hav e the ability to replicate itself. This step will take time because this is a random process. After self-replication, RNAs will undergo a process similar to natural selection. 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